Proteome-wide discovery at the scale your research demands
Protein measurements across thousands of samples. Absolute quantification. Costs that fit a discovery budget.
The Nomic Platform makes high-throughput profiling possible for drug discovery
Cost efficient
Generate large proteomic datasets cost-effectively (~$50/sample), enabling well-powered studies.
Quantitative & interoperable
Generate standardized (pg/mL) measurements that translate seamlessly across studies and integrate directly into downstream drug development workflows.
Proteome-wide & scalable
Measure over 1000 carefully curated proteins selected to capture biologically meaningful signals at scale.
Proteomics discovery
in practice
Uncovering how immune cells respond to perturbations
In a large-scale PBMC perturbation dataset, Nomic’s high-plex secretome profiling reveals that many critical cytokine responses are not captured at the RNA level.
Across thousands of samples, protein-level measurements reveal biology that gene expression alone cannot capture. This uncovers signaling pathways and regulatory mechanisms that would otherwise be missed, providing a more complete view of immune response biology.
Revealing protein-level regulators of microglial activation
Understanding how genes regulate microglial activation requires direct measurement of functional outputs. In CRISPRi screens of iPSC-derived microglia, Nomic’s Omni 1000 reveals that key regulators of chemokine expression are only detectable at the protein level, as are markers of cell death and receptor shedding. This provides a direct readout of immune function in complex culture systems that transcriptomic approaches fail to capture.
Earlier detection and deeper insights for toxicity assesment
Sensitive detection of toxic effects requires capturing both early signals and underlying biology. In large-scale toxicity studies, Nomic’s Omni 1000 identifies lower points of departure for approximately half of tested compounds compared to conventional assays.
Omni 1000 resolves mechanisms of toxicity, including immunotoxic, cytotoxic, mitochondrial, and lysosomal effects. By distinguishing these responses with a single assay, it enables a more precise understanding of compound impact and more confident safety decisions.
Proteomics that supports you all the way
From discovery screening to R&D and cohort studies, Nomic provides a service that scales with your projects. Whether using Omni 1000, context-specific Core options, or even a tailored Flex panel designed to your objectives, you can adapt your approach without compromising data quality or cross study compatibility.
Discovery
- Protein Discovery
- Target ID
- Tx biomarker Discovery
- Indication Selection
Drug RnD
- Protein Discovery
- Target ID
- Tx biomarker Discovery
- Indication Selection
Translational
- Protein Discovery
- Target ID
- Tx biomarker Discovery
- Indication Selection
Omni 1000: Biological Intelligence Delivered at Scale
Resources for discovery teams
Your researchproject deserves a protein answer
Our scientists have designed proteomics studies across target ID,perturbationbiology,MoA, and early toxicity. Share the specifics of your program, and we will tell you what is possible.
